Connecting Data to People

Integrated Testing Strategy for Skin Sensitisation

Allergic contact dermatitis (aka., skin sensitisation) accounts for 20% of all contact dermatitis cases and has an estimated annual cost of $200 million. It is also a public health problem, responsible for more than seven million outpatient visits annually. Currently, there are more than 3700 substances that are identified as contact allergens.

Douglas Connect provides an open implementation of the integrated testing strategy (ITS) that assesses skin sensitisation potency based on an approach developed at Proctor and Gamble.

The DC-ITS implementation combines information from three validated alternative assays (DPRA, KeratinoSens and h-CLAT) with in silico predictions for bioavailability using open cheminformatics tools from the community.

DC-ITS allows scientists to evaluate the skin sensitisation hazard of their chemicals using a combination of in vitro and in silico tools. It automatically compensates for the missing experimental data by using predicted values and utilizes the expert-knowledge embedded in the skin sensitization adverse outcome pathway (AOP). More

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Edelweiss Connect (4 weeks ago)
Read our latest #SaferWorldbydesign newsletter highlighting SaferSkin™ new features and products. #SaferSkin… https://t.co/z9SmrlJ3Yb
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Curation of drug-induced mechanistic toxicological processes and adverse outcome pathway in (DILI) Presented by Cu… https://t.co/8n0QoR3gXa
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The approach may be further extended by additional in silico and in vitro methods to strengthen the weight of evide… https://t.co/oLCdYGMTnW
Edelweiss Connect (4 weeks ago)
Our #SaferSkin™ app implements three well-adopted approaches to perform an integrated analysis of the OECD-approved… https://t.co/MA7DY0RdwO
Edelweiss Connect (6 weeks ago)
#SaferWorldbyDesign & @MultiCASEInc present: Use of in silico methods for assessing toxicity #QSAR #insilico… https://t.co/AgoolrhT7M

Get in touch

  • Address: Edelweiss Connect GmbH
    Technology Park Basel
    Hochbergerstrasse 60C
    CH-4057 Basel / Basel-Stadt
    Switzerland

USA office

  • Address: Edelweiss Connect Inc
    Research Triangle Park NC
    800 Park Offices Dr
    Durham, NC 27709
    USA