OpenTox was initiated as a collaborative project coordinated by EwC and involving a combination of enterprise, university and government research groups to develop a framework, that provides a unified access to toxicity data, (Q)SAR models, procedures supporting validation and additional information that helps with the interpretation of (Q)SAR predictions. In this way, it was the starting point leading to the OpenTox community and follow-up projects like ToxBank, eNanoMapper and OpenRiskNet.