EwC News

1. Introduction: Context, Motivation, and Project Framework Nephrotoxicity Challenge:  Nephrotoxicity, or kidney injury, is a frequent outcome of exposure to a wide variety of xenobiotics and can result in acute and chronic kidney damage. Traditional toxicological assessment methods, such as animal in vivo  studies, are limited by poor predictive capacity and a lack of human relevance. Advantage of hiPSC Models:  A paradigm shift towards in vitro  testing offers new opportuni

Beyond the Cage: Human iPSC Multi-Organ Models Validate Next-Generation Chemical Risk Assessment 1. Motivation and Context Need for New...

Executive Summary The case study leveraged rat in vivo  transcriptomics data  from the DrugMatrix Database to investigate mechanisms of nephrotoxicity. The primary objective was to perform biomarker discovery  by identifying differentially expressed genes (DEGs) specific to toxic compounds compared to non-toxic compounds. The study harmonized data for several nephrotoxic and non-nephrotoxic compounds based on dose and exposure duration. Analysis revealed 109 DEGs found exclus