EwC News

We are excited to share the release of our latest preprint on AOPGraphExplorer , now available on bioRxiv. Adverse Outcome Pathways (AOPs) are foundational to mechanistic toxicology and regulatory science; they map how a molecular perturbation can causally lead to an adverse outcome across levels of biological organization. These frameworks help unify and communicate complex mechanistic evidence for chemical risk assessment and safety evaluation. However, AOP knowledge in exi

New Approach Methodologies (NAMs), including in vitro tests, computational models, and in silico tools, are transforming chemical safety assessment. In many cases, the   required types of data are widely agreed upon, and this is becoming increasingly clear. What is less clear and (not yet standardized) is how this evidence is collected, combined, and reported within an NGRA (Next Generation Risk Assessment) framework. Many NAM-based assessments still rely on fragmented datase

1. Introduction: Context, Motivation, and Project Framework Nephrotoxicity Challenge:  Nephrotoxicity, or kidney injury, is a frequent outcome of exposure to a wide variety of xenobiotics and can result in acute and chronic kidney damage. Traditional toxicological assessment methods, such as animal in vivo  studies, are limited by poor predictive capacity and a lack of human relevance. Advantage of hiPSC Models:  A paradigm shift towards in vitro  testing offers new opportuni