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EwC News
In this Blog space we share our latest news and experiences.
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Case Study in3 Paroquat Toxicity
Beyond the Cage: Human iPSC Multi-Organ Models Validate Next-Generation Chemical Risk Assessment 1. Motivation and Context Need for New...
Oct 7, 20254 min read
Case study in3 DrugMatrix: Toxicogenomic Signatures of Kidney Toxicity: Pinpointing 109 Differentially Expressed Genes in Rat DrugMatrix Data
Executive Summary The case study leveraged rat in vivo transcriptomics data from the DrugMatrix Database to investigate mechanisms of nephrotoxicity. The primary objective was to perform biomarker discovery by identifying differentially expressed genes (DEGs) specific to toxic compounds compared to non-toxic compounds. The study harmonized data for several nephrotoxic and non-nephrotoxic compounds based on dose and exposure duration. Analysis revealed 109 DEGs found exclus
Oct 7, 20253 min read
Beyond Traditional Toxicology: The Power of Toxicogenomics for Early Risk Assessment
In the evolving landscape of chemical and pharmaceutical development, traditional methods of toxicology, which are often heavily reliant on animal testing, are facing increasing scrutiny due to ethical concerns, cost, and time constraints. Enter toxicogenomics, a revolutionary field that is transforming how we assess the safety of compounds. At Edelweiss Connect, through our SaferWorldByDesign initiative, we're at the forefront of leveraging this powerful science for early, e
Oct 7, 20253 min read
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